营养与身体活动及慢性病预防：研究策略与建议

Nutrition and physical activity and chronic disease prevention: research strategies and recommendations.

作者信息

Prentice Ross L, Willett Walter C, Greenwald Peter, Alberts David, Bernstein Leslie, Boyd Norman F, Byers Tim, Clinton Steven K, Fraser Gary, Freedman Laurence, Hunter David, Kipnis Victor, Kolonel Laurence N, Kristal Bruce S, Kristal Alan, Lampe Johanna W, McTiernan Anne, Milner John, Patterson Ruth E, Potter John D, Riboli Elio, Schatzkin Arthur, Yates Allison, Yetley Elizabeth

机构信息

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, M3-A410, Seattle, WA 98109-1024, USA.

出版信息

J Natl Cancer Inst. 2004 Sep 1;96(17):1276-87. doi: 10.1093/jnci/djh240.

DOI:10.1093/jnci/djh240

PMID:15339966

Abstract

A shortage of credible information exists on practical dietary and physical activity patterns that have potential to reverse the national obesity epidemic and reduce the risk of major cancers and other chronic diseases. Securing such information is a challenging task, and there is considerable diversity of opinion concerning related research designs and priorities. Here, we put forward some perspectives on useful methodology and infrastructure developments for progress in this important area, and we list high-priority research topics in the areas of 1) assessment of nutrient intake and energy expenditure; 2) development of intermediate outcome biomarkers; 3) enhancement of cohort and cross-cultural studies; and 4) criteria for and development of full-scale nutrition and physical activity intervention trials.

摘要

目前缺乏关于切实可行的饮食和身体活动模式的可靠信息，而这些模式有可能扭转全国性的肥胖流行趋势，并降低患主要癌症和其他慢性病的风险。获取此类信息是一项具有挑战性的任务，而且在相关研究设计和重点方面存在相当大的意见分歧。在此，我们就这一重要领域取得进展所需的有用方法和基础设施发展提出一些观点，并列出以下领域的高优先级研究课题：1）营养摄入和能量消耗评估；2）中间结果生物标志物的开发；3）队列研究和跨文化研究的加强；4）全面营养和身体活动干预试验的标准及开发。