Cardillo C, Degen C, De Felice F, Folli G
Istituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, Rome, Italy.
Clin Pharmacol Ther. 1992 May;51(5):555-61. doi: 10.1038/clpt.1992.62.
An ideal antihypertensive drug should reduce blood pressure not only at rest but also during stressful situations. To test whether this criterion is fulfilled by celiprolol, a new beta 1-selective adrenergic blocker drug with peripheral vasodilating activity, we examined the effects of its oral administration on cardiovascular reactivity to laboratory stressors in 18 patients with essential hypertension, according to a placebo-controlled crossover design. In the 12 patients classified as "responders," celiprolol significantly reduced resting systolic and diastolic blood pressure (p less than 0.05 for both). Compared with placebo, celiprolol induced a blood pressure reduction from 179.4 +/- 16.9/119.5 +/- 12.4 mm Hg to 160.7 +/- 12.6/109.4 +/- 3.1 mm Hg during mental arithmetic; from 200.9 +/- 20.7/139.2 +/- 11.9 mm Hg to 184.1 +/- 16.4/127.6 +/- 12.1 mm Hg during handgrip test; from 212.8 +/- 18.5/126.2 +/- 14.2 mm Hg to 185.9 +/- 18.2/117.1 +/- 15.2 mm Hg during cycle ergometry. Our data suggest that in the majority of treated patients celiprolol is effective in reducing blood pressure not only at rest but also during a variety of stressful events, thereby ameliorating the impact of recurring stress-induced increases of blood pressure on the cardiovascular system.
一种理想的抗高血压药物不仅应在静息时降低血压，而且应在应激状态下降低血压。为了测试具有外周血管舒张活性的新型β1选择性肾上腺素能阻滞剂塞利洛尔是否符合这一标准，我们根据安慰剂对照交叉设计，研究了18例原发性高血压患者口服该药对实验室应激源的心血管反应性的影响。在被归类为“反应者”的12例患者中，塞利洛尔显著降低了静息时的收缩压和舒张压（两者p均小于0.05）。与安慰剂相比，塞利洛尔在进行心算时使血压从179.4±16.9/119.5±12.4mmHg降至160.7±12.6/109.4±3.1mmHg；在进行握力测试时从200.9±20.7/139.2±11.9mmHg降至184.1±16.4/127.6±12.1mmHg；在进行蹬车运动测试时从212.8±18.5/126.2±14.2mmHg降至185.9±18.2/117.1±15.2mmHg。我们的数据表明，在大多数接受治疗的患者中，塞利洛尔不仅在静息时有效降低血压，而且在各种应激事件期间也有效，从而减轻了反复出现的应激诱导的血压升高对心血管系统的影响。
