Hensley Lisa E, Fritz Lisa E, Jahrling Peter B, Karp Christopher L, Huggins John W, Geisbert Thomas W
Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
Emerg Infect Dis. 2004 Feb;10(2):317-9. doi: 10.3201/eid1002.030482.
A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive effort is under way to identify and test promising antiviral drugs. Here, we report that recombinant human interferon-beta 1a potently inhibits SARS coronavirus replication in vitro.
2003年3月，一种新型冠状病毒引发了严重急性呼吸综合征（SARS）的全球大爆发。SARS的迅速出现及其造成的大量疾病和死亡使其成为一个关键的公共卫生问题。由于没有有效的治疗方法，目前正在大力努力识别和测试有前景的抗病毒药物。在此，我们报告重组人干扰素β-1a在体外能有效抑制SARS冠状病毒的复制。
