复发缓解型多发性硬化症患者的骨桥蛋白水平与疾病活动度增加

Osteopontin levels and increased disease activity in relapsing-remitting multiple sclerosis patients.

作者信息

Vogt M H J, Floris S, Killestein J, Knol D L, Smits M, Barkhof F, Polman C H, Nagelkerken L

机构信息

Division of Biomedical Research, TNO Prevention and Health, P.O. Box 2215, 2301 CE Leiden, The Netherlands.

出版信息

J Neuroimmunol. 2004 Oct;155(1-2):155-60. doi: 10.1016/j.jneuroim.2004.06.007.

DOI:10.1016/j.jneuroim.2004.06.007

PMID:15342207

Abstract

Osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within multiple sclerosis (MS) lesions. Recently, we demonstrated that OPN plasma levels were elevated in active relapsing-remitting (RR) MS patients. In this longitudinal study, a trend was observed for OPN serum levels in relation to clinical exacerbations. Moreover, OPN protein levels were significantly elevated 1 month prior to increase of gadolinium (Gd)-enhancing lesion number, whereas no relation was observed between OPN levels and increase in Gd-enhancing lesion volume. Although no robust relation between OPN and disease activity was observed, these data suggest that OPN levels are elevated prior to increased disease activity in RR MS patients.

摘要

骨桥蛋白（OPN）已被确定为在多发性硬化症（MS）病灶中表达的最显著的细胞因子编码基因。最近，我们证明了活动期复发缓解型（RR）MS患者的血浆OPN水平升高。在这项纵向研究中，观察到OPN血清水平与临床病情加重之间存在一种趋势。此外，在钆（Gd）增强病灶数量增加前1个月，OPN蛋白水平显著升高，而OPN水平与Gd增强病灶体积增加之间未观察到相关性。尽管未观察到OPN与疾病活动之间有很强的相关性，但这些数据表明RR MS患者在疾病活动增加之前OPN水平升高。