Airas Laura, Mikkola Jari, Vainio Jani M, Elovaara Irina, Smith David J
Department of Neurology and MediCity Research Laboratory, University of Turku, PO Box 52, 20521Turku, Finland.
J Neuroimmunol. 2006 Aug;177(1-2):132-5. doi: 10.1016/j.jneuroim.2006.05.014. Epub 2006 Jun 30.
Vascular adhesion protein-1 (VAP-1) is an endothelial cell molecule which controls leukocyte infiltration into tissues. Elevated serum soluble VAP-1-levels have been described in certain diseases with an inflammatory component. VAP-1 expression or function has not previously been studied in multiple sclerosis (MS). We report here that the concentration of soluble VAP-1 in serum is significantly higher in multiple sclerosis patients with ongoing inflammatory activity, as demonstrated by gadolinium-enhancing MRI lesions, when compared to patients with no gadolinium-enhancing lesions (555+/-195 vs. 388+/-102 ng/ml, p=0.0068). We propose that VAP-1 might participate in controlling leukocyte entry into inflamed brain.
血管黏附蛋白-1（VAP-1）是一种内皮细胞分子，可控制白细胞向组织内浸润。在某些具有炎症成分的疾病中，血清可溶性VAP-1水平会升高。此前尚未对多发性硬化症（MS）中的VAP-1表达或功能进行研究。我们在此报告，与无钆增强病变的患者相比，钆增强MRI病变显示有持续炎症活动的多发性硬化症患者血清中可溶性VAP-1的浓度显著更高（555±195对388±102 ng/ml，p = 0.0068）。我们认为VAP-1可能参与控制白细胞进入发炎的大脑。
