鸟分枝杆菌内广泛的基因组多态性。
Extensive genomic polymorphism within Mycobacterium avium.
作者信息
Semret Makeda, Zhai Gary, Mostowy Serge, Cleto Cynthia, Alexander David, Cangelosi Gerard, Cousins Debby, Collins Desmond M, van Soolingen Dick, Behr Marcel A
机构信息
McGill University Health Center, Montreal, Quebec, Canada.
出版信息
J Bacteriol. 2004 Sep;186(18):6332-4. doi: 10.1128/JB.186.18.6332-6334.2004.
Abstract
We have initiated comparative genomic analysis of Mycobacterium avium subspecies by DNA microarray, uncovering 14 large sequence polymorphisms (LSPs) comprising over 700 kb that distinguish M. avium subsp. avium from M. avium subsp. paratuberculosis. Genes predicted to encode metabolic pathways were overrepresented in the LSPs, and analysis revealed a polymorphism within the mycobactin biosynthesis operon that potentially explains the in vitro mycobactin dependence of M. avium subsp. paratuberculosis.
摘要
我们已通过DNA微阵列启动了鸟分枝杆菌亚种的比较基因组分析，发现了14个大序列多态性（LSP），其长度超过700 kb，可区分鸟分枝杆菌亚种鸟分枝杆菌和副结核分枝杆菌亚种。预测编码代谢途径的基因在LSP中过度表达，分析揭示了分枝杆菌素生物合成操纵子内的一个多态性，这可能解释了副结核分枝杆菌亚种在体外对分枝杆菌素的依赖性。
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