Tao H Y, Chen H J, Zhang H, Guo J, Rong F K
Department of Diving Physiology, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
Undersea Biomed Res. 1992 May;19(3):159-69.
Four male divers were exposed to an environment of 26 and 31 atm abs He-O2 for 2 days. Urine was collected during the day (0700-1900 h) and at night (1900-0700 h) before (predive 1 atm abs air), during, and after (decompression and postdive 1 atm abs air) the exposure. Urine flow increased markedly and was mostly attributable to the urine flow during 1900-0700 h. The secretion of atrial natriuretic polypeptide (ANP) increased only at night during hyperbaria. On the other hand, the secretion of antidiuretic hormone (ADH) was suppressed, but increased during compression and the early phase of hyperbaric exposure before it decreased. Linear regression analysis showed that urinary excretion of ANP was correlated significantly with urine flow (r = 0.88, P less than 0.01) and that excretion of ADH negatively correlated with urine flow (r = -0.61, P less than 0.01). Urinary excretion of Na, Cl, Ca, and Mg increased significantly at night during hyperbaria, whereas there was no consistent change in the excretion of K and P. These results suggest that both stimulated ANP secretion and suppressed ADH secretion correlate with the increase of urine and that nocturia is mostly attributable to stimulated ANP secretion. We observed that urinary excretion of ANP increased significantly as early as during the compression phase, which suggested that ANP plays a decisive role in the early diuresis.
四名男性潜水员在26和31绝对大气压的氦氧环境中暴露2天。在白天（07:00 - 19:00）和夜间（19:00 - 07:00）收集尿液，分别在暴露前（潜水前1绝对大气压空气）、暴露期间以及暴露后（减压和潜水后1绝对大气压空气）进行。尿量显著增加，且主要归因于19:00 - 07:00期间的尿量。心房利钠多肽（ANP）的分泌仅在高压期间的夜间增加。另一方面，抗利尿激素（ADH）的分泌受到抑制，但在加压期间和高压暴露的早期阶段增加，之后才下降。线性回归分析表明，ANP的尿排泄量与尿量显著相关（r = 0.88，P < 0.01），而ADH的排泄量与尿量呈负相关（r = -0.61，P < 0.01）。在高压期间的夜间，尿中钠、氯、钙和镁的排泄量显著增加，而钾和磷的排泄量没有一致的变化。这些结果表明，ANP分泌增加和ADH分泌受抑制均与尿量增加相关，夜尿症主要归因于ANP分泌增加。我们观察到，早在加压阶段ANP的尿排泄量就显著增加，这表明ANP在早期利尿中起决定性作用。
