Wilkie J S, Wilkie B N, Yager J A, Eyre P
Department of Pathology, Ontario Veterinary College, University of Guelph, Canada.
Vet Immunol Immunopathol. 1992 Jan 15;30(2-3):129-45. doi: 10.1016/0165-2427(92)90134-c.
Spontaneous, histamine-induced and Concanavalin A (Con A)-induced suppression of Con A mitogenesis of autologous responder cells was studied in normal dogs and in dogs with atopic dermatitis. Histamine-induced suppression was significantly decreased in the atopic dogs, as was the Con A-induced suppression, at supraoptimal concentration of Con A, to a lesser extent. Total numbers of histamine type 1 or type 2 receptors were not different for cells from atopic or normal dogs. The spontaneous suppression was significantly greater for the atopic dogs and this was not accounted for by the effect of non-specific dermatitis, increased macrophage-induced suppression or increased induction by mitogenic factors in the culture medium. Some possible mechanisms for these results are discussed, and the similarities to suppressor cell function in humans with atopic disease are noted.
在正常犬和患特应性皮炎的犬中，研究了自体反应细胞的自发性、组胺诱导性和刀豆蛋白A（Con A）诱导性对Con A有丝分裂原作用的抑制情况。在特应性犬中，组胺诱导的抑制作用显著降低，在Con A超最佳浓度下，Con A诱导的抑制作用也有一定程度的降低。特应性犬和正常犬的细胞中组胺1型或2型受体的总数没有差异。特应性犬的自发性抑制作用明显更强，这不能用非特异性皮炎的影响、巨噬细胞诱导的抑制作用增加或培养基中有丝分裂因子诱导作用增加来解释。讨论了这些结果的一些可能机制，并指出了与特应性疾病患者抑制细胞功能的相似之处。
