Alhadlaq Adel, Mao Jeremy J
Tissue Engineering Laboratory, Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Stem Cells Dev. 2004 Aug;13(4):436-48. doi: 10.1089/scd.2004.13.436.
Mesenchymal stem cells (MSCs) are progenitors of all connective tissue cells. In adults of multiple vertebrate species, MSCs have been isolated from bone marrow (BM) and other tissues, expanded in culture, and differentiated into several tissue-forming cells such as bone, cartilage, fat, muscle, tendon, liver, kidney, heart, and even brain cells. Recent advances in the practical end of application of MSCs toward regeneration of a human-shaped articular condyle of the synovial joint is one example of their functionality and versatility. The present review not only outlines several approaches relevant to the isolation and therapeutic use of MSCs, but also presents several examples of phenotypic and functional characterization of isolated MSCs and their progeny.
间充质干细胞（MSCs）是所有结缔组织细胞的祖细胞。在多种脊椎动物物种的成体中，MSCs已从骨髓（BM）和其他组织中分离出来，在培养中扩增，并分化为多种组织形成细胞，如骨、软骨、脂肪、肌肉、肌腱、肝脏、肾脏、心脏，甚至脑细胞。MSCs在滑膜关节人形成关节髁再生应用实际端的最新进展就是其功能和多功能性的一个例子。本综述不仅概述了与MSCs分离和治疗用途相关的几种方法，还展示了分离的MSCs及其子代的表型和功能特征的几个例子。
