Frankenberg-Dinkel Nicole
Institute for Microbiology, Technical University Braunschweig, Braunschweig, Germany.
Antioxid Redox Signal. 2004 Oct;6(5):825-34. doi: 10.1089/ars.2004.6.825.
The importance of heme oxygenases in heme catabolism, iron utilization, and cellular signaling has been recognized for many years and is a well studied process in eukaryotes. Through the accessibility of an increasing number of bacterial genomes, it has become evident that heme oxygenases are also widespread in prokaryotes. In these organisms, the heme oxygenase reaction serves a similar function as in eukaryotes. A major role of bacterial heme oxygenases has been attributed to acquisition of iron in prokaryotic pathogens, but other functions, such as involvement in phytobilin biosynthesis, have been described. This review summarizes the current state of the art on bacterial heme oxygenase research. The various biological roles of this enzyme in prokaryotes and their biochemical properties will be discussed.
血红素加氧酶在血红素分解代谢、铁利用和细胞信号传导中的重要性已被认识多年，并且在真核生物中是一个经过充分研究的过程。随着越来越多细菌基因组的可得性，很明显血红素加氧酶在原核生物中也广泛存在。在这些生物体中，血红素加氧酶反应与在真核生物中发挥类似的功能。细菌血红素加氧酶的一个主要作用被认为是在原核病原体中获取铁，但也有其他功能被描述，例如参与藻胆素生物合成。本综述总结了细菌血红素加氧酶研究的当前进展。将讨论该酶在原核生物中的各种生物学作用及其生化特性。
