Challa Venkat R, Thore Clara R, Moody Dixon M, Anstrom John A, Brown William R
Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
J Alzheimers Dis. 2004 Aug;6(4):379-83; discussion 443-9. doi: 10.3233/jad-2004-6404.
String vessels are collagenous structures connected to capillaries. They have no endothelial cells or lumen. We assessed collagen IV-labeled string vessels in the white matter (WM) of subjects with Alzheimer's disease (AD) (n = 12) and non-AD controls (n = 11) using 100 microm celloidin sections. Ten standard fields were digitally captured and the number and length of normal vessels and string vessels were quantified by computerized image analysis. The WM of the AD-diagnosed individuals contained more strings per mm2 (3.95 +/- 0.49) than comparable WM from controls (1.36 +/- 0.39) (p = 0.0005) and had increased total string vessel length in mm/mm2 (AD = 0.29 +/- 0.04; control = 0.10 +/- 0.03; p = 0.0015). There was a 25% increase (not statistically significant) in vessel density in mm/mm2 in AD subjects (AD = 11.88 +/- 0.87; control = 9.53 +/- 0.78; p = 0.06), presumably due to brain atrophy in the white matter. Although vessel length was slightly increased in AD subjects, they still had more than double the string length per total vessel length (AD = 2.88 +/- 0.38) compared to controls (1.36 +/- 0.27) (p = 0.0057). This increase in string vessels in the white matter of AD subjects suggests a decrease in vascular supply in this disease.
条索状血管是与毛细血管相连的胶原结构。它们没有内皮细胞和管腔。我们使用100微米厚的火棉胶切片，评估了阿尔茨海默病（AD）患者（n = 12）和非AD对照者（n = 11）白质（WM）中胶原IV标记的条索状血管。数码采集了10个标准视野，并通过计算机图像分析对正常血管和条索状血管的数量及长度进行了量化。AD诊断个体的白质每平方毫米所含条索状血管数量（3.95±0.49）多于对照组的相应白质（1.36±0.39）（p = 0.0005），且每平方毫米条索状血管的总长度增加（AD = 0.29±0.04；对照组 = 0.10±0.03；p = 0.0015）。AD患者每平方毫米血管密度增加了25%（无统计学意义）（AD = 11.88±0.87；对照组 = 9.53±0.78；p = 0.06），推测是由于白质脑萎缩所致。尽管AD患者的血管长度略有增加，但与对照组相比，他们每总血管长度的条索状血管长度仍增加了一倍多（AD = 2.88±0.38）（对照组 = 1.36±0.27）（p = 0.0057）。AD患者白质中条索状血管的增加表明该疾病中血管供应减少。
