Lin Carol Ren, Toychiev Abduqodir, Ablordeppey Reynolds Kwame, Srinivas Miduturu, Benavente-Perez Alexandra
Department of Biological Sciences, SUNY College of Optometry, New York, NY, United States.
Front Med (Lausanne). 2023 Aug 4;10:1112396. doi: 10.3389/fmed.2023.1112396. eCollection 2023.
The retinal vasculature supplies oxygen and nutrition to the cells and is crucial for an adequate retinal function. In myopia, excessive eye growth is associated with various anatomical changes that can lead to myopia-related complications. However, how myopia-induced ocular growth affects the integrity of the aged retinal microvasculature at the cellular level is not well understood. Here, we studied how aging interacts with myopia-induced alteration of the retinal microvasculature in fourteen marmoset retinas (). String vessel and capillary branchpoint were imaged and quantified in all four capillary plexi of the retinal vasculature. As marmosets with lens-induced myopia aged, they developed increasing numbers of string vessels in all four vascular plexi, with increased vessel branchpoints in the parafoveal and peripapillary retina and decreased vessel branchpoints in the peripheral retina. These myopia-induced changes to the retinal microvasculature suggest an adaptive reorganization of the retinal microvascular cellular structure template with aging and during myopia development and progression.
视网膜血管系统为细胞提供氧气和营养，对视网膜的正常功能至关重要。在近视中，眼球过度生长与各种解剖学变化相关，这些变化可能导致近视相关并发症。然而，近视引起的眼球生长如何在细胞水平上影响老年视网膜微血管系统的完整性尚不清楚。在这里，我们研究了衰老如何与近视引起的视网膜微血管系统改变在14只狨猴视网膜中相互作用。对视网膜血管系统的所有四个毛细血管丛中的弦状血管和毛细血管分支点进行成像和定量分析。随着晶状体诱导近视的狨猴年龄增长，它们在所有四个血管丛中出现的弦状血管数量增加，在黄斑旁和视乳头周围视网膜中的血管分支点增加，而在周边视网膜中的血管分支点减少。这些近视引起的视网膜微血管系统变化表明，随着衰老以及在近视发展和进展过程中，视网膜微血管细胞结构模板发生了适应性重组。
