Valbuena Gustavo, Jordan Jeffrey M, Walker David H
Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.
J Infect Dis. 2004 Oct 1;190(7):1221-7. doi: 10.1086/423819. Epub 2004 Aug 18.
Rickettsioses are severe infections caused by obligately intracellular bacteria that preferentially infect the endothelium lining the vasculature. The causative agents, rickettsiae, have been divided according to biological, genetic, and antigenic parameters into 2 main groups: spotted fever and typhus. They have not been thought to stimulate cross-reactive protective immune responses; however, in this study, we show that, in relevant animal models that mimic human rickettsial infections, there is reciprocal immunological cross-protection between spotted fever group and typhus group rickettsiae. Furthermore, we present evidence that T cells are responsible for this cross-immunity and that cross-stimulation of T cells also occurs in humans.
立克次体病是由专性细胞内细菌引起的严重感染，这些细菌优先感染血管系统的内皮细胞。病原体立克次体根据生物学、遗传学和抗原参数分为两个主要组：斑点热组和斑疹伤寒组。以往认为它们不会刺激交叉反应性保护性免疫反应；然而，在本研究中，我们表明，在模拟人类立克次体感染的相关动物模型中，斑点热组和斑疹伤寒组立克次体之间存在相互免疫交叉保护。此外，我们提供的证据表明，T细胞是这种交叉免疫的原因，并且T细胞的交叉刺激在人类中也会发生。
