Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Med Microbiol Immunol. 2017 Dec;206(6):403-417. doi: 10.1007/s00430-017-0514-1. Epub 2017 Aug 2.
Rickettsiae are small intracellular bacteria that can cause life-threatening febrile diseases. Rickettsioses occur worldwide with increasing incidence. Therefore, a vaccine is highly desired. A prerequisite for the development of a vaccine is the knowledge of the immune response against these bacteria, in particular protective immunity. In recent years murine models of rickettsial infections have been established, and the study of immune response against rickettsiae in mice provided many new insights into protective and pathological immune reactions. This review summarizes the current knowledge about immune mechanisms in protection and pathology in rickettsial infections.
立克次氏体是一种可以引起危及生命的发热性疾病的小型细胞内细菌。立克次氏体病在全球范围内发生，发病率不断上升。因此，人们非常希望有一种疫苗。疫苗开发的一个前提是了解针对这些细菌的免疫反应，特别是保护性免疫。近年来，已经建立了立克次体感染的小鼠模型，并且对立克次体感染中免疫反应的研究对立克次体的保护性和病理性免疫反应提供了许多新的见解。本文综述了关于立克次体感染中保护性和病理性免疫机制的最新知识。
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