Fernández E, Gil F J, Ginebra M P, Driessens F C, Planell J A, Best S M
Department of Materials Science and Metallurgy, Universitat Politecnica de Catalunya, Avda. Diagonal 647, 08028-Barcelona, Spain.
J Mater Sci Mater Med. 1999 Mar;10(3):177-83. doi: 10.1023/a:1008989525461.
Calcium phosphate bone cements (CPBC) have been of great interest in medicine and dentistry due to their excellent biocompatibility and bone-repair properties. In this article, a review is presented of the scientific literature concerning precipitate formation during setting reactions of CPBCs. Firstly, the available information has been classified according to the intended final product or calcium phosphate formed during setting reactions. Taking the final product into account, a second classification has been made according to the calcium phosphates present in the original powder mixture. This is the most natural classification procedure because it is based on thermodynamic reasons supported by solubility diagrams for the calcium phosphate salts. By understanding the thermodynamics of calcium phosphate salts in an aqueous solution at room or body temperature it is possible to optimize the manufacturing technology involved in the production of CPBCs. Knowledge of the limitations of this thermodynamic approach opens up new possibilities in the search for CPBCs with better in vitro and in vivo properties for clinical applications.
磷酸钙骨水泥（CPBC）因其出色的生物相容性和骨修复特性而在医学和牙科领域备受关注。本文对有关CPBC凝固反应过程中沉淀形成的科学文献进行了综述。首先，已有的信息根据预期的最终产物或凝固反应过程中形成的磷酸钙进行了分类。考虑到最终产物，又根据原始粉末混合物中存在的磷酸钙进行了二次分类。这是最自然的分类方法，因为它基于热力学原理，并得到了磷酸钙盐溶解度图的支持。通过了解室温或体温下水溶液中磷酸钙盐的热力学性质，可以优化CPBC生产过程中的制造技术。了解这种热力学方法的局限性为寻找具有更好的体外和体内性能以用于临床应用的CPBC开辟了新的可能性。
