School of Materials Science and Engineering, South China University of Technology, 510641, Guangzhou, China.
National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, 510006, Guangzhou, China.
J Mater Sci Mater Med. 2018 Dec 3;29(12):183. doi: 10.1007/s10856-018-6193-7.
The inferior anti-washout property of injectable calcium phosphate cement (CPC) limits its wider application in clinic. In this study, the improvement of anti-washout performance of CPC by addition of konjac glucomannan or guar gum, which was dissolved in the CPC liquid, was first studied. The influence of KGM/GG blend with different mass ratios on the anti-washout property, compressive strength and in vitro cytocompatibility of CPC was estimated. The results revealed that small amount of KGM or GG could obviously enhance the anti-washout property of CPC. Moreover, the washout resistance efficiency of KGM/GG blend was better than KGM or GG alone. The addition of KGM/GG blend slightly shortened the final setting time of CPC. Although the introduction of KGM/GG blend reduced the compressive strength of CPC, the compressive strength still reached or surpassed that of human cancellous bone. The best KGM/GG mass ratio was 5:5, which was most efficient at not only reducing CPC disintegration, but also increasing compressive strength. The addition of KGM/GG blend obviously promoted the cells proliferation on the CPC. In short, the CPC modified by KGM/GG blend exhibited excellent anti-washout property, appropriate setting time, adequate compressive strength, and good cytocompatibility, and has the potential to be used in bone defect repair. The addition of KGM/GG blend significantly improved the anti-washout property of CPC. The best KGM/GG mass ratio was 5:5, which was most efficient in reducing the CPC disintegration.
注射型磷酸钙骨水泥（CPC）较差的抗冲刷性能限制了其在临床上的广泛应用。本研究首次通过添加魔芋葡甘聚糖（KGM）或瓜尔胶（GG）来改善 CPC 的抗冲刷性能，研究了不同质量比的 KGM/GG 混合物对 CPC 的抗冲刷性能、抗压强度和体外细胞相容性的影响。结果表明，少量的 KGM 或 GG 可以明显提高 CPC 的抗冲刷性能。此外，KGM/GG 混合物的抗冲刷效率优于 KGM 或 GG 单独使用。KGM/GG 混合物的加入略微缩短了 CPC 的最终凝固时间。尽管 KGM/GG 混合物的引入降低了 CPC 的抗压强度，但仍达到或超过了人松质骨的抗压强度。KGM/GG 的最佳质量比为 5:5，不仅能有效降低 CPC 的崩解，还能提高抗压强度。KGM/GG 混合物的加入明显促进了细胞在 CPC 上的增殖。总之，经 KGM/GG 混合物改性的 CPC 具有优异的抗冲刷性能、适当的凝固时间、足够的抗压强度和良好的细胞相容性，有望用于骨缺损修复。KGM/GG 混合物的加入显著提高了 CPC 的抗冲刷性能。KGM/GG 的最佳质量比为 5:5，在降低 CPC 崩解方面最为有效。
