Gottfried Oren N, Schmidt Meic H, Stevens Edwin A
Department of Neurosurgery, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.
Neurosurg Focus. 2003 Aug 15;15(2):E4. doi: 10.3171/foc.2003.15.2.4.
The management of sacral tumors is challenging because of difficulties in accessing the lesion, the high rate of local recurrence, extensive vascularity causing significant intraoperative blood loss, resistance to radiation therapy, and risk of malignant transformation. Although surgery is the main treatment for many sacral tumors, embolization is a valuable primary and adjunctive therapy. Patients with benign lesions, including aneurysmal bone cysts and giant cell tumors, have responded to embolization with resolution of their symptoms and with ossification of their lesions. Embolization is used as a primary therapy for metastatic lesions and results in neurological improvement, reduced tumor size, and decreased spinal canal compromise. It is also used as an adjuvant therapy to reduce intraoperative blood loss and to aid in the resection of benign, malignant, and metastatic sacral lesions. It is important to note that embolization techniques are a valuable resource in the treatment of sacral tumors, and, overall, embolization should always be considered in patients with sacral tumors.
由于骶骨肿瘤的病变部位难以触及、局部复发率高、血管丰富导致术中失血量大、对放射治疗耐药以及有恶变风险,其治疗颇具挑战性。尽管手术是许多骶骨肿瘤的主要治疗方法,但栓塞是一种有价值的主要及辅助治疗手段。患有良性病变(包括骨囊肿和巨细胞瘤)的患者对栓塞治疗有反应,症状得以缓解,病变发生骨化。栓塞用作转移性病变的主要治疗方法,可改善神经功能、缩小肿瘤大小并减轻椎管受压。它还用作辅助治疗,以减少术中失血,并有助于切除良性、恶性及转移性骶骨病变。需要注意的是,栓塞技术是治疗骶骨肿瘤的宝贵资源,总体而言,骶骨肿瘤患者应始终考虑进行栓塞治疗。