幻觉体验与精神障碍的发作：有证据表明，这种风险是由妄想形成介导的。
Hallucinatory experiences and onset of psychotic disorder: evidence that the risk is mediated by delusion formation.
作者信息
Krabbendam L, Myin-Germeys I, Hanssen M, Bijl R V, de Graaf R, Vollebergh W, Bak M, van Os J
机构信息
Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands.
出版信息
Acta Psychiatr Scand. 2004 Oct;110(4):264-72. doi: 10.1111/j.1600-0447.2004.00343.x.
OBJECTIVE
To examine the hypothesis that the risk for onset of psychotic disorder in individuals with self-reported hallucinatory experiences (HE) would be higher in those who developed delusional ideation (DE) than in those who did not.
METHOD
A population sample of 4673 individuals were interviewed with the Composite International Diagnostic Interview at baseline and 1 and 3 years later. At year 3, clinical re-interview took place to identify onset of psychotic disorder.
RESULTS
Given the presence of HEs at baseline, the increase in risk of having the psychosis outcome at year 3 was much higher in those with DE at year 1 than in those without DE (risk difference between individuals with and without DE: 18.72%, 95% CI: 2.22-35.23, chi(2) = 4.94, df = 1, P = 0.026).
CONCLUSION
The results are in line with current psychological theories stating that clinical outcome of psychosis-like experiences is related to the development of secondary beliefs and appraisals.
目的
检验如下假设：自我报告有幻觉体验（HE）的个体中，出现妄想观念（DE）的个体发生精神障碍的风险高于未出现妄想观念的个体。
方法
对4673名个体组成的人群样本在基线时、1年后和3年后进行综合国际诊断访谈。在第3年进行临床再次访谈以确定精神障碍的发病情况。
结果
鉴于基线时存在幻觉体验，第1年有妄想观念的个体在第3年出现精神病结局的风险增加幅度远高于无妄想观念的个体（有和无妄想观念个体的风险差异：18.72%，95%可信区间：2.22 - 35.23，χ² = 4.94，自由度 = 1，P = 0.026）。
结论
结果与当前心理学理论相符，该理论认为类似精神病体验的临床结局与继发性信念和评估的发展有关。
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