高效抗逆转录病毒治疗6年后病毒学抑制患者循环CD4 T淋巴细胞的长期变化
Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy.
作者信息
Smith Kimberly, Aga Evgenia, Bosch Ronald J, Valdez Hernan, Connick Elizabeth, Landay Alan, Kuritzkes Daniel, Gross Barry H, Francis Isaac R, McCune Joseph M, Kessler Harold, Lederman Michael
机构信息
Department of Infectious Diseases, Rush Medical College of Rush University, Chicago, IL 60612, USA.
出版信息
AIDS. 2004 Sep 24;18(14):1953-6. doi: 10.1097/00002030-200409240-00012.
Highly active antiretroviral therapy (HAART) initiated in advanced HIV disease is associated with CD4 lymphocyte increases (200-300 cells/mm3 after 2-4 years), although longer-term cellular dynamics have not been studied. We observed a significant median CD4 lymphocyte increase of 126 cells/mm3 and 54 naive CD4 lymphocytes from year 3 to 6 of HAART among 20 individuals with pre-HAART CD4 cell counts of 100-300 cells/mm3. This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART.
在晚期HIV疾病中启动的高效抗逆转录病毒疗法（HAART）与CD4淋巴细胞增加有关（2至4年后增加200 - 300个细胞/mm³），尽管尚未对长期的细胞动态变化进行研究。在20名HAART治疗前CD4细胞计数为100 - 300个细胞/mm³的个体中，我们观察到从HAART治疗第3年到第6年，CD4淋巴细胞中位数显著增加了126个细胞/mm³，幼稚CD4淋巴细胞增加了54个。该队列代表了对接受HAART且病毒学抑制的患者进行的最长时间的前瞻性免疫学随访。
Zotero 插件