Persson E, Berg S, Trollfors B, Larsson P, Ek E, Backhaus E, Claesson B E B, Jonsson L, Rådberg G, Ripa T, Johansson S
Department of Paediatrics, The Queen Silvia Children's Hospital, S-416 85 Göteborg, Sweden.
Clin Microbiol Infect. 2004 Sep;10(9):791-6. doi: 10.1111/j.1469-0691.2004.00931.x.
This study monitored the serotypes of Streptococcus agalactiae (group B streptococcus; GBS) isolated from invasive infections in western Sweden and investigated possible relationships between serotype, age and clinical manifestations. Invasive GBS isolates were collected prospectively during 1998-2001 at six laboratories, covering two counties with a population of 1.8 million, and were serotyped by coagglutination. Clinical data were obtained from hospital notes. In total, 161 invasive strains (50 from neonates and infants aged < 3 months, and 111 from adults) were serotyped. The commonest serotypes from neonates and infants were serotypes III (60%), V (22%) and Ia (10%), and from adults were serotypes V (42%) and III (25%). Serotype V had doubled in frequency among both children and adults compared to a previous study from the same area in 1988-1997. Most (80%) of the adults had an underlying medical condition. No relationship was found between serotype and clinical manifestations. However, the study demonstrated the importance of active surveillance of GBS serotypes and the difficulties of formulating a multivalent polysaccharide conjugate vaccine against GBS.
本研究监测了从瑞典西部侵袭性感染中分离出的无乳链球菌（B组链球菌；GBS）的血清型，并调查了血清型、年龄和临床表现之间的可能关系。1998年至2001年期间，前瞻性地在六个实验室收集了侵袭性GBS分离株，覆盖了两个县，人口为180万，并通过协同凝集法进行血清分型。临床数据从医院病历中获取。总共对161株侵袭性菌株（50株来自3个月以下的新生儿和婴儿，111株来自成人）进行了血清分型。新生儿和婴儿中最常见的血清型是III型（60%）、V型（22%）和Ia型（10%），成人中是V型（42%）和III型（25%）。与1988年至1997年同一地区的先前研究相比，V型血清型在儿童和成人中的频率都增加了一倍。大多数（80%）成人有潜在的医疗状况。未发现血清型与临床表现之间的关系。然而，该研究证明了对GBS血清型进行主动监测的重要性以及制定针对GBS的多价多糖结合疫苗的困难。
