Yoou Myoung-Schook, Jeong Ji Hun, Ihm Chunhwa
Department of Laboratory Medicine, Daejeon Eulji Medical Center, Eulji University, Daejeon, Republic of Korea.
Can J Infect Dis Med Microbiol. 2025 Aug 29;2025:8797954. doi: 10.1155/cjid/8797954. eCollection 2025.
This study aims to determine the molecular features and antimicrobial resistance of (Group B streptococcus, GBS) causing invasive and noninvasive infections in Korean adults. Sequence type (ST), capsular serotype, pilus island typing, and antimicrobial susceptibility were analyzed for GBS isolates obtained at a hospital laboratory that processed the primary clinical specimens collected from Korean adults between 2021 and 2024. Among the 90 isolates, Serotype VIII (34.4%) was the most common, followed by V (17.8%), Ia (12.2%), VI (11.1%), II (10.0%), and Ib (6.7%). Every isolate contained at least one PI gene, of which PI2a (37.8%) was the most frequently observed combination. The combination of PI1 and PI2b was present in 34.4% of isolates, followed by PI1 and PI2a (24.4%) and PI2b alone (3.3%). Among the 18 STs identified, the capsular serotype VIII/ST2-clonal complex 1 (CC1) was dominant (34.4%), followed by V or VI/ST1 (12.2%). All isolates were susceptible to both ampicillin and vancomycin, while antibiotic resistances were observed for erythromycin (27.8%), levofloxacin (13.3%), clindamycin (25.6%), and tetracycline (47.8%), respectively. These data are key elements to help design prevention and treatment strategies for GBS infection in Korean adults.
本研究旨在确定导致韩国成年人侵袭性和非侵袭性感染的B族链球菌（GBS）的分子特征及抗菌耐药性。对2021年至2024年期间在一家医院实验室获得的GBS分离株进行了序列类型（ST）、荚膜血清型、菌毛岛分型及抗菌药敏分析，该实验室处理了从韩国成年人采集的原始临床标本。在90株分离株中，血清型VIII（34.4%）最为常见，其次是V型（17.8%）、Ia型（12.2%）、VI型（11.1%）、II型（10.0%）和Ib型（6.7%）。每株分离株至少含有一个PI基因，其中PI2a（37.8%）是最常观察到的组合。PI1和PI2b的组合存在于34.4%的分离株中，其次是PI1和PI2a（24.4%）以及单独的PI2b（3.3%）。在鉴定出的18种ST中，荚膜血清型VIII/ST2 - 克隆复合体1（CC1）占主导地位（34.4%），其次是V型或VI型/ST1（12.2%）。所有分离株对氨苄西林和万古霉素均敏感，而对红霉素（27.8%）、左氧氟沙星（13.3%）、克林霉素（25.6%）和四环素（47.8%）分别观察到了抗生素耐药性。这些数据是帮助设计韩国成年人GBS感染预防和治疗策略的关键要素。
