Nishimoto Y, Odaka M, Hirata K, Yuki N
Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan.
J Neuroimmunol. 2004 Mar;148(1-2):200-5. doi: 10.1016/j.jneuroim.2003.11.017.
Fisher syndrome (FS), a variant of Guillain-Barré syndrome (GBS), is a rare disorder, and there are few reported studies of a large number of patients with FS. Cerebrospinal fluid (CSF) albuminocytological dissociation was found in 59% of 123 FS patients during the first 3 weeks of illness, while serum anti-GQ1b IgG antibody was positive in 85%. Whereas the incidence of CSF albuminocytological dissociation increased from the first to second weeks in FS, anti-GQ1b IgG antibody peaked in the first week, but there was no CSF albuminocytological dissociation. Statistically, anti-GQ1b antibody testing was superior to a CSF examination in supporting a diagnosis of FS during the first 3 weeks of illness, especially in the first week.
费希尔综合征（FS）是吉兰 - 巴雷综合征（GBS）的一种变体，是一种罕见疾病，关于大量FS患者的报道研究较少。在123例FS患者病程的前3周内，59%的患者脑脊液（CSF）出现蛋白细胞分离现象，而85%的患者血清抗GQ1b IgG抗体呈阳性。在FS中，脑脊液蛋白细胞分离的发生率从第一周升至第二周，而抗GQ1b IgG抗体在第一周达到峰值，但此时并无脑脊液蛋白细胞分离现象。从统计学角度来看，在疾病的前3周，尤其是第一周，抗GQ1b抗体检测在支持FS诊断方面优于脑脊液检查。
