Wikler J R, Nieboer C, Willemze R
Department of Dermatology, Free University Hospital, Amsterdam, The Netherlands.
J Am Acad Dermatol. 1992 Jul;27(1):37-9. doi: 10.1016/0190-9622(92)70153-7.
Previous studies have suggested that Pityrosporum yeasts may be important in the pathogenesis of seborrheic dermatitis (SD). SD occurs more frequently and has a different clinical appearance in patients who are human immunodeficiency virus (HIV)-seropositive than in HIV-seronegative patients.
Our purpose was to investigate the role of Pityrosporum yeasts in the pathogenesis of seborrheic dermatitis in HIV-seropositive patients.
Twenty-eight HIV-seropositive patients, including seven patients with SD and 21 without SD, and 20 HIV-seronegative patients with SD (n = 10) and without SD (n = 10) were investigated. Quantitative Pityrosporum cultures were taken from the face, chest, and back.
None or only a small amount of Pityrosporum yeasts were cultured from SD lesions and SD predilection sites in HIV-seropositive patients. From the SD lesions in the HIV-seronegative control group large amounts of Pityrosporum yeasts were cultured.
The results of this and other studies suggest that Pityrosporum yeasts play no role in SD in HIV-seropositive patients and that SD in these patients is a distinct entity to be separated from "classical" SD in HIV-seronegative patients.
既往研究表明，马拉色菌酵母可能在脂溢性皮炎（SD）的发病机制中起重要作用。与人类免疫缺陷病毒（HIV）血清学阴性患者相比，HIV血清学阳性患者脂溢性皮炎的发病率更高，临床表现也有所不同。
我们的目的是研究马拉色菌酵母在HIV血清学阳性患者脂溢性皮炎发病机制中的作用。
对28例HIV血清学阳性患者（包括7例患有脂溢性皮炎和21例未患脂溢性皮炎的患者）以及20例HIV血清学阴性患者（10例患有脂溢性皮炎和10例未患脂溢性皮炎）进行了研究。从面部、胸部和背部采集马拉色菌定量培养样本。
在HIV血清学阳性患者的脂溢性皮炎皮损和脂溢性皮炎好发部位未培养出马拉色菌酵母或仅培养出少量马拉色菌酵母。在HIV血清学阴性对照组的脂溢性皮炎皮损中培养出大量马拉色菌酵母。
本研究及其他研究结果表明，马拉色菌酵母在HIV血清学阳性患者的脂溢性皮炎中不起作用，这些患者的脂溢性皮炎是一种与HIV血清学阴性患者的“经典”脂溢性皮炎不同的疾病实体。
