Groisser D, Bottone E J, Lebwohl M
Department of Medicine, Mount Sinai Hospital, New York, NY.
J Am Acad Dermatol. 1989 May;20(5 Pt 1):770-3. doi: 10.1016/s0190-9622(89)70088-8.
The possible causative role of the yeastlike fungus Pityrosporum (Malassezia) orbiculare in the pathogenesis of seborrheic dermatitis in patients with and without acquired immunodeficiency syndrome (AIDS) has been discussed but not resolved. Ten patients with AIDS-related seborrheic dermatitis were studied for the presence of Pityrosporum organisms. On the basis of a quantitative correlation between numbers of yeast cells adherent to and extruded from keratinocytes and the clinical severity of seborrheic dermatitis, an association, if not a causative role, for Pityrosporum is strongly suggested in seborrheic dermatitis in patients with AIDS. This association was further strengthened by the marked clinical response to ketoconazole in two patients with a concomitant decrease in the number of Pityrosporum cells per keratinocyte.
卵圆形糠秕孢子菌（马拉色菌）在伴有和不伴有获得性免疫缺陷综合征（AIDS）患者脂溢性皮炎发病机制中可能的致病作用已被讨论，但尚未明确。对10例艾滋病相关脂溢性皮炎患者进行了糠秕孢子菌检测。基于角质形成细胞上附着和挤出的酵母细胞数量与脂溢性皮炎临床严重程度之间的定量相关性，强烈提示糠秕孢子菌在艾滋病患者脂溢性皮炎中存在关联，即便不是致病作用。两名患者使用酮康唑后临床症状显著改善，同时每个角质形成细胞中糠秕孢子菌细胞数量减少，这进一步加强了这种关联。
