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Selective inhibition of cough and bronchoconstriction in conscious guinea pigs.

作者信息

Forsberg K, Karlsson J A, Zackrisson C, Persson C G

机构信息

Astra Draco AB, Lund, Sweden.

出版信息

Respiration. 1992;59(2):72-6. doi: 10.1159/000196030.

Abstract

In guinea-pigs citric acid-induced cough and bronchoconstriction were inhibited by beta 2-agonist and xanthine drugs. Lidocaine inhibited only cough. Cromoglycate and ipratropium bromide inhibited only bronchoconstriction. We conclude that cough and bronchoconstriction in guinea-pigs are distinct reflexes and that the inhibitory pharmacology of these airway reflexes may agree in many respects, with that observed in asthmatic subjects.

摘要

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