通过钯（0）催化的2-（2'，3'-联烯基）丙二酸酯与有机卤化物的偶联-环化反应，高度区域选择性和立体选择性地合成多取代环丙烷化合物。
Highly regio- and stereoselective synthesis of polysubstituted cyclopropane compounds via the Pd(0)-catalyzed coupling-cyclization reaction of 2-(2',3'-allenyl)malonates with organic halides.
作者信息
Ma Shengming, Jiao Ning, Yang Qing, Zheng Zilong
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, PR China.
出版信息
J Org Chem. 2004 Sep 17;69(19):6463-6. doi: 10.1021/jo049323u.
A new method for highly regio- and stereoselective synthesis of polysubstituted cyclopropane compounds via the Pd(0)-catalyzed coupling-cyclization reaction of 2-(2',3'-allenyl)malonates with organic halides is described. In these reactions, the starting materials are easily available and the operation is convenient. The ratios of trans-isomer/cis-vinylic cyclopropanes are up to 98:2.
描述了一种通过钯（0）催化2-（2'，3'-烯丙基）丙二酸酯与有机卤化物的偶联-环化反应高度区域和立体选择性合成多取代环丙烷化合物的新方法。在这些反应中，起始原料易于获得且操作方便。反式异构体/顺式乙烯基环丙烷的比例高达98:2。
Zotero 插件