钯（0）催化的2-（2'，3'-联烯基）乙酰乙酸酯与有机卤化物的偶联环化反应：4,5-二氢呋喃衍生物的高效合成
Pd(0)-catalyzed coupling-cyclization of 2-(2',3'-allenyl)acetylacetates and organic halides: an efficient synthesis of 4,5-dihydrofuran derivatives.
作者信息
Ma Shengming, Zheng Zilong, Jiang Xuefeng
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, P. R. China.
出版信息
Org Lett. 2007 Feb 1;9(3):529-31. doi: 10.1021/ol0628917.
PMID:17249804
Abstract
[reaction: see text] Highly chemo- and regioselective Pd(0)-catalyzed coupling-cyclization of 2-(2',3'-allenyl)acetylacetates with organic halides using K3PO4 as base in DMF efficiently afforded 4,5-dihydrofuran derivatives in moderate to excellent yields, with a selectivity of >97:3.
摘要
[反应：见正文] 以磷酸钾为碱，在N,N-二甲基甲酰胺中，钯(0)高效催化2-(2',3'-联烯基)乙酰乙酸酯与有机卤化物进行高度化学选择性和区域选择性的偶联环化反应，以中等至优异的产率得到4,5-二氢呋喃衍生物，选择性大于97:3。
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