Hansen Lars, Jones Roland Morgan, Kingdon David
Department of Psychiatry, University of Southampton Royal South Hants, Hospital, Southampton, UK.
J Psychopharmacol. 2004 Sep;18(3):384-7. doi: 10.1177/026988110401800309.
Akathisia and drug-induced Parkinsonism have traditionally been associated with depression and suicidality based on case study evidence. In this subanalysis, patients with treatment resistant schizophrenia were rated on the Comprehensive Psychopathological Rating Scale, Barnes Akathisia Scale and Simpson-Angus extrapyramidal side-effect scale at two time points (n=86 at first assessment; n=67 at second assessment). At no time point was there any significant relationship between akathisia and depression/suicidality or distress associated with akathisia and Parkinsonism with suicidality. These preliminary findings warrant further investigation.
基于病例研究证据，静坐不能和药物性帕金森综合征传统上一直与抑郁和自杀倾向相关。在这项亚分析中，对难治性精神分裂症患者在两个时间点使用综合精神病理学评定量表、巴恩斯静坐不能量表和辛普森-安格斯锥体外系副作用量表进行评定（首次评估时n = 86；第二次评估时n = 67）。在任何时间点，静坐不能与抑郁/自杀倾向之间，或与静坐不能和帕金森综合征相关的痛苦与自杀倾向之间均无显著关系。这些初步发现值得进一步研究。
