a Department of Psychiatry , GMERS General Hospital and Medical College , Vadodara , India.
b Department of Pharmacology , GMERS Medical College , Vadodara , India.
Int J Psychiatry Clin Pract. 2018 Jun;22(2):101-108. doi: 10.1080/13651501.2017.1381268. Epub 2017 Sep 27.
To assess prevalence and pattern of movement disorders among patients taking antipsychotic medications.
This cross-sectional, intensive monitoring (patient interview, case record form review and clinical examination) study was conducted in patients taking antipsychotic drugs irrespective of duration for the development of movement disorders. The psychiatrist used Modified Simpson-Angus Scale score (10-item scale), Barnes' rating scale and Abnormal Involuntary Movement Scale to diagnose parkinsonism, akathisia and tardive dyskinesia, respectively. We assessed movement disorders for the preventability and seriousness.
The overall prevalence of antipsychotic induced movement disorders was 5.67% (95% CI: 4.19-7.62). The prevalence of parkinsonism, akathisia and tardive dyskinesia was 5.10% (95% CI: 3.71-6.98), 0.85% (95% CI: 0.39-1.84) and 0.57% (95% CI: 0.22-1.45), respectively. There was a trend of high proportions of movement disorders in extreme of age group, female gender, patients treated with conventional antipsychotics, on poly therapy, patients of epilepsy with psychosis, schizophrenia and bipolar mood disorder. The movement disorder was lowest with quetiapine (2.02%).
The higher use of atypical antipsychotics had reduced the occurrence of movement disorders in our setup.
评估服用抗精神病药物的患者出现运动障碍的患病率和模式。
本横断面、强化监测（患者访谈、病历回顾和临床检查）研究纳入了正在服用抗精神病药物的患者，无论其出现运动障碍的持续时间如何。精神科医生使用改良辛普森-安格斯量表评分（10 项量表）、巴恩斯评定量表和异常不自主运动量表分别诊断帕金森病、静坐不能和迟发性运动障碍。我们评估了运动障碍的可预防性和严重程度。
抗精神病药引起的运动障碍总患病率为 5.67%（95%CI：4.19-7.62）。帕金森病、静坐不能和迟发性运动障碍的患病率分别为 5.10%（95%CI：3.71-6.98）、0.85%（95%CI：0.39-1.84）和 0.57%（95%CI：0.22-1.45）。在年龄极端、女性、使用传统抗精神病药物、多药治疗、伴有精神病的癫痫患者、精神分裂症和双相情感障碍患者中，运动障碍的比例较高。在本研究中，喹硫平（2.02%）的运动障碍发生率最低。
在我们的研究中，使用非典型抗精神病药物的比例较高，降低了运动障碍的发生。
