Kölsch H, Heun R, Kerksiek A, Bergmann K V, Maier W, Lütjohann D
Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.
Neurosci Lett. 2004 Sep 30;368(3):303-8. doi: 10.1016/j.neulet.2004.07.031.
Alterations in brain cholesterol metabolism and reduced 24S-hydroxycholesterol plasma levels have been described in Alzheimer's disease (AD) and vascular dementia (VD). We hypothesize that changes in peripheral cholesterol metabolism, such as alterations in the plasma levels of 27-hydroxycholesterol, might also be involved. Plasma levels of 24S-hydroxycholesterol and 27-hydroxycholesterol in patients suffering from dementing disorders such as AD, VD, and mild cognitive impairment (MCI) were compared to those in age- and cholesterol matched non-demented and depressed subjects. Cholesterol corrected concentrations of plasma 24S-hydroxycholesterol and 27-hydroxycholesterol were significantly reduced in patients with dementing disorders compared to non-demented subjects and depressed patients. A strong positive correlation between plasma 24S-hydroxycholesterol and 27-hydroxycholesterol levels was observed. The ratios of plasma 24S-hydroxycholesterol to 27-hydroxycholesterol were higher in patients with dementing disorders compared to non-demented subjects. Our results support the observation, that cholesterol metabolism is altered in dementing disorders, indicated by different plasma concentrations of brain specific and peripherally produced oxysterols.
阿尔茨海默病（AD）和血管性痴呆（VD）患者存在脑胆固醇代谢改变以及血浆24S-羟基胆固醇水平降低的情况。我们推测外周胆固醇代谢的变化，如27-羟基胆固醇血浆水平的改变，可能也与之相关。将患有痴呆症（如AD、VD和轻度认知障碍（MCI））的患者的血浆24S-羟基胆固醇和27-羟基胆固醇水平与年龄和胆固醇水平匹配的非痴呆及抑郁受试者进行比较。与非痴呆受试者和抑郁患者相比，患有痴呆症的患者经胆固醇校正后的血浆24S-羟基胆固醇和27-羟基胆固醇浓度显著降低。观察到血浆24S-羟基胆固醇和27-羟基胆固醇水平之间存在强正相关。与非痴呆受试者相比，患有痴呆症的患者血浆24S-羟基胆固醇与27-羟基胆固醇的比值更高。我们的结果支持以下观察结果：痴呆症患者的胆固醇代谢发生改变，这由脑特异性和外周产生的氧化甾醇的不同血浆浓度所表明。
