阿尔茨海默病的营养脂质组学。
Nutritional Lipidomics in Alzheimer's Disease.
机构信息
Department of Informatics Ionian University, Bioinformatics and Human Electrophysiology Lab (BiHeLab), Corfu, Greece.
出版信息
Adv Exp Med Biol. 2020;1195:95-104. doi: 10.1007/978-3-030-32633-3_14.
Lipids constitute almost 60% of the brain's dry weight, and they are thought to be involved in inflammation, neurotransmission and synaptic plasticity. The brain mostly contains sphingolipids, glycerophospholipids and cholesterol which are abundant in myelin and neuronal membranes. The recent rise of the promising area of lipidomic data can be used as a diagnosing tool at the early stages of Alzheimer's disease allowing novel therapeutic targets. In this review, altered lipid metabolites as well as the impact of diet in the progress of Alzheimer's disease (AD) are analyzed.
脂质占大脑干重的近 60%，被认为与炎症、神经递质传递和突触可塑性有关。大脑中含有丰富的鞘脂、甘油磷脂和胆固醇，它们存在于髓鞘和神经元膜中。脂质组学数据这一极具前景的领域最近有了新的进展，可以作为阿尔茨海默病早期诊断的工具，为新的治疗靶点提供依据。本综述分析了脂质代谢物的变化以及饮食对阿尔茨海默病（AD）进展的影响。
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