Weigel Thaddeus K, Kulas Joshua A, Ferris Heather A
Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, U.S.A.
Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA 22908, U.S.A.
Neuronal Signal. 2019 Dec;3(4):NS20190068. doi: 10.1042/NS20190068. Epub 2019 Nov 28.
Type 2 diabetes is associated with adverse central nervous system effects, including a doubled risk for Alzheimer's disease (AD) and increased risk of cognitive impairment, but the mechanisms connecting diabetes to cognitive decline and dementia are unknown. One possible link between these diseases may be the associated alterations to cholesterol oxidation and metabolism in the brain. We will survey evidence demonstrating alterations to oxysterols in the brain in AD and diabetes and how these oxysterols could contribute to pathology, as well as identifying research questions that have not yet been addressed to allow for a fuller understanding of the role of oxysterols in AD and diabetes.
2型糖尿病与中枢神经系统不良影响相关，包括患阿尔茨海默病（AD）的风险加倍以及认知障碍风险增加，但将糖尿病与认知衰退和痴呆联系起来的机制尚不清楚。这些疾病之间的一个可能联系可能是大脑中胆固醇氧化和代谢的相关改变。我们将调查证据，证明AD和糖尿病患者大脑中氧化甾醇的改变，以及这些氧化甾醇如何导致病理变化，同时确定尚未解决的研究问题，以便更全面地了解氧化甾醇在AD和糖尿病中的作用。
