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Mutant cardiac ryanodine receptors and ventricular arrhythmias: is 'gain-of-function' obligatory?

作者信息

Gomez Ana Maria, Richard Sylvain

出版信息

Cardiovasc Res. 2004 Oct 1;64(1):3-5. doi: 10.1016/j.cardiores.2004.07.018.

DOI:10.1016/j.cardiores.2004.07.018
PMID:15364606
Abstract
摘要

相似文献

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Mutant cardiac ryanodine receptors and ventricular arrhythmias: is 'gain-of-function' obligatory?突变型心脏兰尼碱受体与室性心律失常:“功能获得”是必需的吗?
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Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release.内质网钙离子测量结果显示,与心律失常和猝死相关的心脏雷诺丁受体突变改变了钙库过载诱导的钙离子释放阈值。
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Life, sudden death, and intracellular calcium.
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Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death.与心源性猝死相关的兰尼碱受体突变的功能异质性。
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Arrhythmogenic mutation-linked defects in ryanodine receptor autoregulation reveal a novel mechanism of Ca2+ release channel dysfunction.与致心律失常突变相关的兰尼碱受体自身调节缺陷揭示了钙离子释放通道功能障碍的新机制。
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Sarcoplasmic reticulum calcium leak and cardiac arrhythmias.肌浆网钙泄漏与心律失常。
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Cardiac ryanodine receptor gene (hRyR2) mutation underlying catecholaminergic polymorphic ventricular tachycardia in a Chinese adolescent presenting with sudden cardiac arrest and cardiac syncope.一名中国青少年因心脏骤停和心源性晕厥就诊,其儿茶酚胺能多形性室性心动过速的潜在病因是心脏雷诺丁受体基因(hRyR2)突变。
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Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death.增强的肌浆网钙超载诱导的钙释放以及通道对管腔钙激活的敏感性是与室性心动过速和猝死相关的兰尼碱受体2(RyR2)突变的常见缺陷。
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Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy.非缺血性心肌病中的心肌能量代谢
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Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase.心肌兰尼碱受体(Ryr2)介导的钙信号通过丙酮酸脱氢酶特异性促进葡萄糖氧化。
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Ageing-related cardiomyocyte functional decline is sex and angiotensin II dependent.
与衰老相关的心肌细胞功能衰退具有性别和血管紧张素II依赖性。
Age (Dordr). 2014 Jun;36(3):9630. doi: 10.1007/s11357-014-9630-7. Epub 2014 Feb 25.
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Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice.心脏兰尼碱受体控制成年小鼠的心率和节律性。
Cardiovasc Res. 2012 Dec 1;96(3):372-80. doi: 10.1093/cvr/cvs260. Epub 2012 Aug 6.
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Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca2+ release channels.由细胞内钙离子释放通道突变引起的心脏和骨骼肌疾病。
J Clin Invest. 2005 Aug;115(8):2033-8. doi: 10.1172/JCI25664.