Dalpiaz Anthony S, Lordon Stephen P, Lipman Arthur G
Department of Pharmacy Services, University Hospitals and Clinics, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA.
J Pain Palliat Care Pharmacother. 2004;18(3):15-34.
An open label study of topical lidocaine 5% patches was conducted for myofascial pain management based on the hypothesis that electrical dysfunction is a component of myofascial pain and therefore sodium channel blockade may be useful in managing myofascial pain. The efficacy of topical lidocaine patch therapy for myofascial pain impact of the therapy on associated quality of life were investigated in the one-month trial. Principal outcome measures were Brief Pain Inventory- Short Form for pain intensity and quality of life score changes. Twenty-seven patients with moderate-severe myofascial pain were enrolled. Eighteen had low back pain. Two patients reported complete pain relief and 3 reported a lot of relief. Mean improvements for average pain intensity (7, 14, and 28 days), general activity (7 and 28 days), mood and sleep (7, 14, and 28 days), walking (14 and 28 days), and ability to work, relationships, and enjoyment of life (28 days) were significant (P < 0.05). These results suggest lidocaine patches may be useful in the management of myofascial pain.
基于电功能障碍是肌筋膜疼痛的一个组成部分，因此钠通道阻滞可能有助于治疗肌筋膜疼痛这一假设，开展了一项关于5% 复方利多卡因贴剂用于肌筋膜疼痛治疗的开放性研究。在为期一个月的试验中，研究了复方利多卡因贴剂治疗肌筋膜疼痛的疗效及其对相关生活质量的影响。主要结局指标为简明疼痛量表简表中的疼痛强度和生活质量评分变化。招募了27例中重度肌筋膜疼痛患者。其中18例有腰痛。2例患者报告疼痛完全缓解，3例报告疼痛明显缓解。平均疼痛强度（第7、14和28天）、一般活动（第7和28天）、情绪和睡眠（第7、14和28天）、行走（第14和28天）以及工作能力、人际关系和生活乐趣（第28天）的平均改善具有显著性（P < 0.05）。这些结果表明，利多卡因贴剂可能有助于治疗肌筋膜疼痛。
