Bózzola F G, Gorelick P B, Freels S
Department of Neurological Sciences, Rush Medical College, Chicago, Ill. 60612.
Arch Neurol. 1992 Mar;49(3):297-300. doi: 10.1001/archneur.1992.00530270117027.
We profiled personality changes that were measured cross-sectionally on the Blessed Dementia Scale in 80 patients with Alzheimer's disease who were examined at a dementia clinic. The most common personality changes were diminished initiative/growing apathy (61.3%), relinquishment of hobbies (55.0%), and increased rigidity (41.3%). The least frequent personality change was sexual misdemeanor (3.8%). Discriminant function analysis showed that the Global Deterioration Scale, the Clinical Rating Scale for Symptoms of Psychosis in Alzheimer's Disease, and the duration of dementia symptoms were the best predictors to classify personality change in an overall score of personality. However, cognitive impairment, as measured by the Blessed Memory-Information-Concentration Test and Mini-Mental State Examination, was not a good predictor of overall personality change. Personality and behavioral changes are common in Alzheimer's disease and may not be attributed entirely to intellectual impairment.
我们对80名在痴呆症诊所接受检查的阿尔茨海默病患者进行了横断面研究，通过Blessed痴呆量表测量其人格变化。最常见的人格变化是主动性降低/冷漠加剧（61.3%）、放弃爱好（55.0%）以及僵化加剧（41.3%）。最不常见的人格变化是性行为不检（3.8%）。判别函数分析表明，总体衰退量表、阿尔茨海默病精神病症状临床评定量表以及痴呆症状持续时间是在人格总体评分中对人格变化进行分类的最佳预测指标。然而，通过Blessed记忆-信息-注意力测试和简易精神状态检查表测量的认知障碍并不是总体人格变化的良好预测指标。人格和行为变化在阿尔茨海默病中很常见，可能并不完全归因于智力损害。
