Revenu Céline, Athman Rafika, Robine Sylvie, Louvard Daniel
UMR144 Centre National de la Recherche Scientifique/Institut Curie, Paris, France.
Nat Rev Mol Cell Biol. 2004 Aug;5(8):635-46. doi: 10.1038/nrm1437.
Cells have various surface architectures, which allow them to carry out different specialized functions. Actin microfilaments that are associated with the plasma membrane are important for generating these cell-surface specializations, and also provide the driving force for remodelling cell morphology and triggering new cell behaviour when the environment is modified. This phenomenon is achieved through a tight coupling between cell structure and signal transduction, a process that is modulated by the regulation of actin-binding proteins.
细胞具有多种表面结构，这使其能够执行不同的特殊功能。与质膜相关的肌动蛋白微丝对于产生这些细胞表面特化结构很重要，并且在环境发生改变时，还为重塑细胞形态和触发新的细胞行为提供驱动力。这种现象是通过细胞结构与信号转导之间的紧密耦合实现的，这一过程由肌动蛋白结合蛋白的调节来调控。
