口蹄疫：足体、侵袭性伪足和环形背侧褶皱

Foot and mouth: podosomes, invadopodia and circular dorsal ruffles.

作者信息

Buccione Roberto, Orth James D, McNiven Mark A

机构信息

Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Santa Maria Imbaro (Chieti), Italy.

出版信息

Nat Rev Mol Cell Biol. 2004 Aug;5(8):647-57. doi: 10.1038/nrm1436.

DOI:10.1038/nrm1436

PMID:15366708

Abstract

The plasma membrane of many motile cells undergoes highly regulated protrusions and invaginations that support the formation of podosomes, invadopodia and circular dorsal ruffles. Although they are similar in appearance and in their formation--which is mediated by a highly conserved actin-membrane apparatus--these transient surface membrane distortions are distinct. Their function is to help the cell as it migrates, attaches and invades.

摘要

许多运动细胞的质膜会经历高度调控的突起和内陷，这些过程支持了足体、侵袭性伪足和环形背侧褶皱的形成。尽管它们在外观和形成过程上相似——由高度保守的肌动蛋白-膜装置介导——但这些短暂的表面膜变形是不同的。它们的功能是在细胞迁移、附着和侵袭时提供帮助。