炎症刺激激活会增加1型人类免疫缺陷病毒与中性粒细胞的结合以及随后淋巴细胞的感染。
Activation by inflammatory stimuli increases neutrophil binding of human immunodeficiency virus type 1 and subsequent infection of lymphocytes.
作者信息
Gabali Ali M, Anzinger Joshua J, Spear Gregory T, Thomas Larry L
机构信息
Department of Immunology/Microbiology, Rush University Medical Center, 1653 W. Congress Pkwy., Chicago, IL 60612, USA.
出版信息
J Virol. 2004 Oct;78(19):10833-6. doi: 10.1128/JVI.78.19.10833-10836.2004.
Abstract
Resting neutrophils bind human immunodeficiency virus type 1 (HIV-1) and efficiently transfer infection to lymphocytes. The present study shows that a brief activation by inflammatory stimuli increases the neutrophil binding levels of both R5 and X4 isolates of HIV-1 at least twofold. The binding occurs independently of CD4, gp120, and incubation temperature and is observed with HIV-1 propagated either in lymphocytes or in HEK293 cells. Significantly, HIV-1 bound to the activated neutrophils accelerates the infection of activated lymphocytes compared to free HIV-1 or to HIV-1 bound to resting neutrophils. It is proposed that these events may contribute to the increased risk of HIV-1 transmission at sites of mucosal infection.
摘要
静息中性粒细胞可结合1型人类免疫缺陷病毒（HIV-1），并有效地将感染传递给淋巴细胞。本研究表明，炎症刺激引起的短暂激活可使HIV-1的R5和X4分离株在中性粒细胞上的结合水平至少提高两倍。这种结合独立于CD4、gp120和孵育温度，并且在淋巴细胞或HEK293细胞中增殖的HIV-1上均能观察到。值得注意的是，与游离HIV-1或与静息中性粒细胞结合的HIV-1相比，与活化中性粒细胞结合的HIV-1可加速活化淋巴细胞的感染。有人提出，这些事件可能导致黏膜感染部位HIV-1传播风险增加。
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2
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