人类RAS超家族蛋白及相关GTP酶
Human RAS superfamily proteins and related GTPases.
作者信息
Colicelli John
机构信息
Department of Biological Chemistry and Molecular Biology Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
出版信息
Sci STKE. 2004 Sep 7;2004(250):RE13. doi: 10.1126/stke.2502004re13.
The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger family of at least 35 related human proteins. Using a somewhat broader definition of sequence similarity reveals a more extended superfamily of more than 170 RAS-related proteins. The RAS superfamily of GTP (guanosine triphosphate) hydrolysis-coupled signal transduction relay proteins can be subclassified into RAS, RHO, RAB, and ARF families, as well as the closely related Galpha family. The members of each family can, in turn, be arranged into evolutionarily conserved branches. These groupings reflect structural, biochemical, and functional conservation. Recent findings have provided insights into the signaling characteristics of representative members of most RAS superfamily branches. The analysis presented here may serve as a guide for predicting the function of numerous uncharacterized superfamily members. Also described are guanosine triphosphatases (GTPases) distinct from members of the RAS superfamily. These related proteins employ GTP binding and GTPase domains in diverse structural contexts, expanding the scope of their function in humans.
肿瘤癌蛋白HRAS、KRAS和NRAS是一个至少由35种相关人类蛋白组成的更大蛋白家族的创始成员。使用对序列相似性稍宽泛一些的定义会揭示一个由超过170种RAS相关蛋白组成的更庞大的超家族。GTP（鸟苷三磷酸）水解偶联信号转导中继蛋白的RAS超家族可细分为RAS、RHO、RAB和ARF家族，以及密切相关的Gα家族。每个家族的成员又可依次排列成进化上保守的分支。这些分组反映了结构、生化和功能上的保守性。最近的研究结果为大多数RAS超家族分支的代表性成员的信号传导特征提供了见解。此处呈现的分析可作为预测众多未表征的超家族成员功能的指南。还描述了与RAS超家族成员不同的鸟苷三磷酸酶（GTP酶）。这些相关蛋白在不同的结构背景中利用GTP结合和GTP酶结构域，扩展了它们在人类中的功能范围。
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