Boguski M S, McCormick F
National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, Maryland 20894.
Nature. 1993 Dec 16;366(6456):643-54. doi: 10.1038/366643a0.
GTPases of the Ras superfamily regulate many aspects of cell growth, differentiation and action. Their functions depend on their ability to alternate between inactive and active forms, and on their cellular localization. Numerous proteins affecting the GTPase activity, nucleotide exchange rates and membrane localization of Ras superfamily members have now been identified. Many of these proteins are much larger and more complex than their targets, containing multiple domains capable of interacting with an intricate network of cellular enzymes and structures.
Ras超家族的GTP酶调节细胞生长、分化和活动的许多方面。它们的功能取决于其在无活性和活性形式之间转换的能力，以及它们在细胞内的定位。现在已经鉴定出许多影响Ras超家族成员的GTP酶活性、核苷酸交换速率和膜定位的蛋白质。这些蛋白质中的许多比它们的靶标要大得多且复杂得多，包含多个能够与复杂的细胞酶和结构网络相互作用的结构域。
