在马兜铃烯合酶催化过程中苯丙氨酸178的双重作用。
Dual role for phenylalanine 178 during catalysis by aristolochene synthase.
作者信息
Forcat Silvia, Allemann Rudolf K
机构信息
School of Chemistry, University of Birmingham, Edgbaston, Birmingham, UKB15 2TT.
出版信息
Chem Commun (Camb). 2004 Sep 21(18):2094-5. doi: 10.1039/b407932a. Epub 2004 Aug 6.
DOI:10.1039/b407932a
PMID:15367991
Abstract
A mutant of aristolochene synthase, in which Phe 178 was replaced by Val, produced significant amounts of alpha-and beta-farnesene as well as alpha and beta-selinene and selina-4,11-diene, suggesting that Phe 178 is involved in the stabilisation of transition states preceding germacrene A and following eudesmane cation.
摘要
一种马兜铃烯合酶突变体，其中苯丙氨酸178被缬氨酸取代，产生了大量的α-和β-法尼烯以及α-和β-芹子烯和4,11-二烯芹子烷，这表明苯丙氨酸178参与了金合欢烯A之前和桉叶烷阳离子之后的过渡态的稳定。
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