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马兜铃烯合酶的酪氨酸92引导法呢基焦磷酸的环化作用。

Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate.

作者信息

Calvert Melanie J, Taylor Susan E, Allemann Rudolf K

机构信息

School of Chemical Sciences, University of Birmingham, Edgbaston, Birmingham, UK B15 2TT.

出版信息

Chem Commun (Camb). 2002 Oct 21(20):2384-5. doi: 10.1039/b206517g.

DOI:10.1039/b206517g
PMID:12430452
Abstract

A mutant of Aristolochene Synthase (AS), in which Tyr 92 was replaced by Val, produced the alicyclic beta-(E)-farnesene as the major product, indicating that cyclisation of FPP is controlled by Tyr 92 in AS.

摘要

一种将天冬氨酸合成酶（AS）中的酪氨酸92替换为缬氨酸的突变体，产生了脂环族β-（E）-法尼烯作为主要产物，这表明在AS中FPP的环化作用受酪氨酸92控制。

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