Wiwanitkit Viroj, Suwansaksri Jamsai, Soogarun Suphan
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Yale J Biol Med. 2003;76(3):103-8.
Benzene exposure is of particular concern because recent research indicating that benzene exposure can result in chronic toxicity, therefore, monitoring for benzene exposure among at-risk workers is recommended. In exposure- and risk-evaluation, the monitoring of benzene by peripheral biomarker has several advantages over technical assessment of exposure. For this purpose, the urine trans, trans muconic acid (ttMA)e level is accepted as a useful monitoring tool for early diagnosis of dangerous exposure. Apart from the industrial workers, there are other occupations with high risk for benzene exposure. In this study, we study another at-risk occupation, the police. Thirty-nine urine samples were obtained from 39 Thai police working close to traffic in an urban area. All 39 samples were analyzed for ttMA level and compared to 10 other controls. The average urine ttMA level for the control and exposed group were < 0.05 mg/gCr and was 0.79 +/- 1.43 mg/gCr, respectively. Significant higher urine ttMA acid level among the police were observed (p <.05). Working in the air pollution in the urban area can be health hazard for the police. Exposure to the benzene from automobile exhaust can be an important occupational problem for these police.
苯暴露尤其令人担忧,因为最近的研究表明苯暴露会导致慢性毒性,因此,建议对高危工人进行苯暴露监测。在暴露和风险评估中,通过外周生物标志物监测苯比暴露的技术评估具有几个优势。为此,尿反式,反式粘康酸(ttMA)水平被认为是早期诊断危险暴露的有用监测工具。除了产业工人外,还有其他职业存在苯暴露的高风险。在本研究中,我们研究了另一个高危职业——警察。从39名在市区靠近交通区域工作的泰国警察那里获取了39份尿液样本。对所有39份样本进行了ttMA水平分析,并与另外10个对照进行比较。对照组和暴露组的尿ttMA平均水平分别<0.05 mg/g肌酐和为0.79±1.43 mg/g肌酐。观察到警察的尿ttMA酸水平显著更高(p<0.05)。在市区空气污染环境中工作可能对警察健康构成危害。接触汽车尾气中的苯可能是这些警察面临的一个重要职业问题。