Liu L, Zhang Q, Feng J
Department of Genotoxicology, Sun Yat-Sen University of Medical Sciences, Guangzhou.
Zhonghua Yu Fang Yi Xue Za Zhi. 1996 May;30(3):148-50.
Urine trans, trans-muconic acid (TTMA) in population exposed to benzene was determined with a high performance liquid chromatography-ultra violet detection system. Result showed urine TTMA increased significantly with increasing of air benzene levels, showing a good correlationship between them (r = 0.940, P < 0.05). Even in relatively low air benzene levels (with an average of 2.46 mg/m3), urine TTMA in exposed group was higher, as compared with that in controls, and their difference reached statistically significant level. It suggests that urine TTMA level can be used as a sensitive and specific indicator for biological monitoring, especially for low exposure to benzene. There was no significant difference in urine TTMA between males and females exposed. Urine TTMA formation can be inhibited by toluene, and confounding of toluene can be roughly adjusted by analysis of covariance.
采用高效液相色谱 - 紫外检测系统测定接触苯人群的尿反式，反式 - 粘康酸（TTMA）。结果显示，尿TTMA随空气中苯水平的升高而显著增加，二者呈现良好的相关性（r = 0.940，P < 0.05）。即使在相对较低的空气中苯水平（平均为2.46 mg/m³）下，与对照组相比，暴露组的尿TTMA仍较高，且差异具有统计学意义。这表明尿TTMA水平可作为生物监测的敏感且特异的指标，尤其是对于低剂量苯暴露。暴露的男性和女性之间尿TTMA无显著差异。甲苯可抑制尿TTMA的形成，通过协方差分析可大致调整甲苯造成的混杂影响。
