Caetano M, Ornstein M P, von Dadelszen P, Hannah M E, Logan A G, Gruslin A, Willan A, Magee Laura A
Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Canada.
Hypertens Pregnancy. 2004;23(2):197-209. doi: 10.1081/PRG-120028295.
How Canadian practitioners are diagnosing and managing the hypertensive disorders of pregnancy (HDP), particularly in relation to the 1997 recommendations published by the Canadian Hypertension Society (CHS), is not known.
A survey, with French and English versions (and covering diagnosis, evaluation, and management of pregnancy hypertension), was mailed to all members of the Society of Obstetricians and Gynaecologists of Canada (SOGC) (N = 1757, including obstetricians, family doctors practicing obstetrics, and midwives). Additionally, internists [i.e., all nephrologists (N = 191) and a random sample of 25% of general internists (N = 450)] registered with the Royal College of Physicians and Surgeons of Canada were sampled. The survey was distributed in two mailings and one reminder card. Data were entered into Microsoft Access, and Graph Pad Prism used to summarize responses [N (%)]. Differences in practice between specialties were examined, with a Bonferonni correction used to calculate a significant p value based on the number of comparisons and alpha of 0.05.
Respondents numbered 1187 (49.5%), with 466 not informative for the purpose of the study (due to retirement, or practices that do not include pregnant women with hypertension). The final analysis included 721 completed surveys. Most (609, 84.5% of) respondents take blood pressure (BP) with women in the sitting position, and use a mercury sphygmomanometer (79%) and the 5th Korotkoff (61%) sound to designate diastolic BP (dBP). To monitor pregnancies complicated by preeclampsia, most clinicians use the proposed laboratory tests of maternal well-being (usually at least once/week), fetal well-being [nonstress test (NST, at least once/week), and ultrasonographic studies (once weekly to every two weeks)]. There is general agreement that women with preeclampsia should be delivered for uncontrolled hypertension, end-organ dysfunction, or fetal compromise (nonreassuring NST, severe oligohydramnios, biophysical profile < 4, estimated fetal weight < 5th centile, and reversed end-diastolic flow by umbilical artery Doppler velocimetry). Less consensus was seen for delivery for preeclampsia at > 34 weeks, mild asymptomatic HELLP syndrome, hyperreflexia, and absent end-diastolic flow by umbilical artery Doppler velocimetry.
This survey has clarified the current state of practice with respect to the diagnosis and evaluation of women with all types of HDP. In particular, we have identified areas of potential variability in BP measurement, and provided data on the feasibility of enrolling women with sub types of preeclampsia into intervention studies aimed at prolonging pregnancy.
目前尚不清楚加拿大的从业者如何诊断和管理妊娠高血压疾病(HDP),尤其是与加拿大高血压协会(CHS)1997年发布的建议相关的情况。
一项涵盖妊娠高血压诊断、评估和管理的调查问卷,有法语和英语版本,被邮寄给加拿大妇产科学会(SOGC)的所有成员(N = 1757,包括产科医生、从事产科工作的家庭医生和助产士)。此外,抽取了在加拿大皇家内科医师和外科医师学院注册的内科医生[即所有肾病学家(N = 191)和25%的普通内科医生随机样本(N = 450)]。该调查问卷分两次邮寄并附带一张提醒卡。数据录入Microsoft Access,使用Graph Pad Prism对回复进行总结[N(%)]。检查各专业之间的实践差异,采用Bonferonni校正根据比较次数和α值0.05计算显著p值。
共有1187名受访者(49.5%),其中466名因退休或其业务不包括患有高血压的孕妇等原因,对本研究无参考价值。最终分析纳入721份完整的调查问卷。大多数受访者(609名,占84.5%)让孕妇坐着测量血压,使用汞柱式血压计(79%)并采用第5期柯氏音(61%)来确定舒张压(dBP)。为监测子痫前期合并妊娠,大多数临床医生采用提议的评估母体健康的实验室检查(通常至少每周一次)、评估胎儿健康[无应激试验(NST,至少每周一次)和超声检查(每周一次至每两周一次)]。普遍认为,子痫前期患者若出现高血压控制不佳、终末器官功能障碍或胎儿窘迫(NST无反应型、严重羊水过少、生物物理评分<4、估计胎儿体重<第5百分位数以及脐动脉多普勒血流速度测定显示舒张末期血流反向)应进行分娩。对于孕周>34周的子痫前期、轻度无症状性HELLP综合征、反射亢进以及脐动脉多普勒血流速度测定显示舒张末期血流消失时是否进行分娩,共识较少。
本次调查明确了各类HDP女性诊断和评估方面的当前实践状况。特别是,我们确定了血压测量中可能存在差异的领域,并提供了有关将子痫前期亚型女性纳入旨在延长孕周的干预研究的可行性数据。