加纳儿童白细胞介素-4基因重复序列和启动子区域的等位基因多态性与疟疾严重程度
Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children.
作者信息
Gyan B A, Goka B, Cvetkovic J T, Kurtzhals J L, Adabayeri V, Perlmann H, Lefvert A-K, Akanmori B D, Troye-Blomberg M
机构信息
Immunology Unit, Noguchi Memorial Institute for Medical Research, Ghana.
出版信息
Clin Exp Immunol. 2004 Oct;138(1):145-50. doi: 10.1111/j.1365-2249.2004.02590.x.
Abstract
Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)-4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between polymorphisms in the IL-4 repeat region (intron 3) and promoter regions (IL-4 +33CT and - 590CT) in Ghanaian children with severe malaria. There was a significantly higher frequency of IL-4 intron-3 B1B1 genotype in the cerebral malaria group [P < 0.0001, odds ratio (OR) = 8.7]. The genotype and allele frequencies of the IL-4 -590 and +33 polymorphisms did not differ between the four study groups. Carriers of IL-4 +33T/-590T with cerebral malaria had elevated total IgE compared to non-carriers (P = 0.03). Our data suggest that IL-4 and/or IgE play a regulatory role in the pathogenesis of severe or complicated malaria.
摘要
免疫球蛋白E与重症疟疾相关，提示白细胞介素（IL）-4和/或IgE在重症疟疾发病机制中起调节作用。我们研究了加纳重症疟疾患儿白细胞介素-4重复区域（内含子3）和启动子区域（IL-4 +33CT和-590CT）多态性之间的可能关联。脑型疟组中IL-4内含子3 B1B1基因型频率显著更高[P < 0.0001，优势比（OR）= 8.7]。四个研究组之间IL-4 -590和+33多态性的基因型和等位基因频率没有差异。与非携带者相比，脑型疟的IL-4 +33T/-590T携带者总IgE升高（P = 0.03）。我们的数据表明，IL-4和/或IgE在重症或复杂疟疾的发病机制中起调节作用。
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