Al-Eitan Laith N, Rababa'h Doaa M, Alghamdi Mansour A, Khasawneh Rame H
Department of Applied Biological Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan.
Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid 22110, Jordan.
Pharmgenomics Pers Med. 2019 Aug 26;12:201-207. doi: 10.2147/PGPM.S220571. eCollection 2019.
Breast cancer (BC) is one of the most widespread cancers globally. Understanding the etiology of BC may help in determining the various risk factors involved in its malignancy. Certain genetic mutations are considered to play a key role in increasing the risk of BC.
In this study, we explored the correlation between a variable number tandem repeat (VNTR) polymorphism in the gene and BC.
PCR and subsequent gel electrophoresis were used to genotype this variant in 360 Jordanian women (180 BC patients and 180 controls). In addition, phenotype-genotype analysis was carried out.
Our findings illustrate that there is no significant relationship between the variant genotypes in the gene and BC among Jordanian females. Other than body mass index and tumor differentiation (< 0.05), none of the clinical and pathological parameters of BC patients exhibited any association with the variant genotypes.
From this study, we propose that the genetic variant does not impact BC development and progression but that it could influence the disease prognosis.
乳腺癌（BC）是全球最常见的癌症之一。了解BC的病因可能有助于确定其恶性肿瘤涉及的各种风险因素。某些基因突变被认为在增加BC风险中起关键作用。
在本研究中，我们探讨了该基因中可变数目串联重复序列（VNTR）多态性与BC之间的相关性。
采用聚合酶链反应（PCR）及随后的凝胶电泳对360名约旦女性（180例BC患者和180例对照）的该变体进行基因分型。此外，还进行了表型-基因型分析。
我们的研究结果表明，该基因的变体基因型与约旦女性的BC之间无显著关系。除体重指数和肿瘤分化外（<0.05），BC患者的临床和病理参数均与变体基因型无任何关联。
从本研究中，我们提出该基因变体不影响BC的发生和发展，但可能影响疾病预后。
