Zacharioudakis George, Chrysos Emmanuel, Athanasakis Elias, Tsiaoussis John, Karmoiris Konstandinos, Xynos Evaghelos
Department of General Surgery, Laboratory Gastrointestinal Motility, University Hospital of Heraklion, Crete, Greece.
Digestion. 2004;70(2):84-92. doi: 10.1159/000080926. Epub 2004 Sep 16.
Colored food substances may interfere with Bilitec system that uses bilirubin as a marker for the detection of duodeno-gastro-esophageal reflux, causing false positive results. Therefore, diets have been suggested for consumption during Bilitec studies that contain minimal amounts of pigments.
To enrich the list of suitable foods for Bilitec measurements with dishes common in Mediterranean diets, and improve subject's compliance.
Ninety substances were in vivo tested for 'bilirubin absorbance'. 'Dry' substances were blended after being diluted in water, while 'floppy' substances and cooked foods were blended undiluted. Blended mixtures and 'liquids' were tested for bilirubin without further dilution and after being mixed with hydrochloric acid. The procedure was repeated to assess reproducibility of the measurements.
Measurements are highly reproducible. Thirty five foods exhibited 'bilirubin absorbance' values safely below the threshold, and are considered to be suitable for Bilitec studies. On the contrary some vegetables and fruits, legumes, tomato sauce preparations, red wine, coffee, tea and jams showed high absorbance values, and are not recommended.
Menus containing part of the variety of Mediterranean food preparations are safely recommended for consumption during Bilitec studies, enriching food lists available at present.
有色食物物质可能会干扰以胆红素作为检测十二指肠-胃-食管反流标志物的Bilitec系统,导致假阳性结果。因此,有人建议在Bilitec研究期间食用色素含量极低的饮食。
用地中海饮食中常见的菜肴丰富适合Bilitec测量的食物清单,并提高受试者的依从性。
对90种物质进行了“胆红素吸光度”的体内测试。“干性”物质在用水稀释后进行混合,而“软性”物质和烹饪过的食物则未经稀释直接混合。对混合后的混合物和“液体”在不进一步稀释以及与盐酸混合后进行胆红素测试。重复该过程以评估测量的可重复性。
测量具有高度可重复性。35种食物的“胆红素吸光度”值安全地低于阈值,被认为适合Bilitec研究。相反,一些蔬菜、水果、豆类、番茄酱制品、红酒、咖啡、茶和果酱显示出高吸光度值,不建议食用。
在Bilitec研究期间,安全推荐食用包含部分地中海食物种类的菜单,从而丰富目前可用的食物清单。