Stathopoulos Angelike, Levine Michael
Dept. of MCB, Division of Genetics, University of California, Berkeley, California 94720-3204, USA.
Curr Opin Genet Dev. 2004 Oct;14(5):477-84. doi: 10.1016/j.gde.2004.07.004.
Microarray assays and bioinformatics methods have identified many of the genes and associated regulatory DNAs that control the early phases of gastrulation in Drosophila. The localized activities of these genes are coordinated by a nuclear gradient of the maternal regulatory factor, Dorsal, that is established shortly after fertilization. At least half of the Dorsal target genes encode transcription factors or signaling components that lead to the restricted activation of FGF, EGF, and TGF-beta signaling pathways in the mesoderm, neurogenic ectoderm and dorsal ectoderm, respectively. Recent work has yielded insights into how these signaling pathways control gastrulation, particularly in the context of the Dorsal-mediated gene regulation network
微阵列分析和生物信息学方法已经鉴定出许多控制果蝇原肠胚形成早期阶段的基因及相关调控DNA。这些基因的局部活性由母体调控因子背腹蛋白（Dorsal）的核梯度协调，该梯度在受精后不久就建立起来。至少一半的背腹蛋白靶基因编码转录因子或信号成分，它们分别导致中胚层、神经外胚层和背外胚层中FGF、EGF和TGF-β信号通路的限制性激活。最近的研究已经深入了解了这些信号通路如何控制原肠胚形成，特别是在背腹蛋白介导的基因调控网络背景下。
