Tullio Vivian, Cuffini Annamaria, Mandras Narcisa, Roana Janira, Banche Giuliana, Ungheri Domenico, Carlone Nicola
Department of Public Health and Microbiology, Microbiology Division, University of Turin, Via Santena 9, 10126 Turin, Italy.
Int J Antimicrob Agents. 2004 Oct;24(4):381-5. doi: 10.1016/j.ijantimicag.2004.03.027.
Current antibiotic therapy encourages the use of antibiotics that may potentiate the host's immune defences. We therefore investigated the effect of thiamphenicol (TAP), the active principle of thiamphenicol glycinate acetylcysteinate (TGA), on human granulocyte functions, mainly phagocytosis and intracellular killing of Streptococcus pyogenes. Our findings support the use of thiamphenicol in the treatment of respiratory tract infections caused by S. pyogenes as it acts directly against the pathogen as well as in cooperation with PMNs by eliciting their intracellular killing.
目前的抗生素疗法鼓励使用可能增强宿主免疫防御的抗生素。因此，我们研究了甲砜霉素（TAP）（甘氨酸乙酰半胱氨酸甲砜霉素（TGA）的活性成分）对人粒细胞功能的影响，主要是对化脓性链球菌的吞噬作用和细胞内杀伤作用。我们的研究结果支持将甲砜霉素用于治疗由化脓性链球菌引起的呼吸道感染，因为它不仅直接作用于病原体，还通过激发中性粒细胞的细胞内杀伤作用与中性粒细胞协同发挥作用。
